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SYDNEY, Feb. 23 (Xinhua) -- Australian scientists have discovered a potent molecule responsible for inflammatory diseases.
In a study published on Thursday, researchers form Melbourne's Walter and Eliza Hall Institute (WEHI) found that an inflammatory molecule released by dying cells triggers inflammation during necroptosis, a form of cell death linked to inflammatory disease.
Necroptosis is a process for protecting humans from infections by sacrificing infected or diseased cells "for the greater good."
However, if necroptosis becomes excessively activated it can trigger damaging inflammation that leads to inflammatory disease.
Lisa Lindqvist, the lead researcher, said that interleukin-1 beta (IL-1b) triggered inflammation during the cell death.
She said the discovery challenged a long-standing dogma that inflammation triggered by necroptosis was a by-product of dead cell debris.
"Our research has pinpointed that, during necroptosis, dying cells release IL-1b, a potent inflammatory signal," Lindqvist said in a media release on Thursday.
"Now that we have discovered IL-1b is the 'root' of the inflammation associated with necroptosis, we speculate that targeting this molecule could be an effective way of treating inflammatory diseases."
Researchers are optimistic that the findings suggest suppressing IL-1b would reduce inflammation associated with inflammatory diseases such as multiple sclerosis (MS), liver disease and pancreatitis.
"Our research suggests that existing drugs that block IL-1b might be useful in treating these diseases," Lindqvist said.
"We are also exploring how IL-1b is signalled to be secreted during necroptosis, so that we can create new drugs to stop its release and reduce inflammation to treat inflammatory diseases."
TEHRAN Cheap Jerseys Discount , Nov. 1 (Xinhua) -- Russian President Putin said in Tehran Wednesday that the nuclear agreement between Iran and the world powers in 2015 is a "good pact in line with expansion of peace and stability in the region."
The Russian President Vladimir Putin was visiting Iran to attend the tripartite summit of Iran, Russia and Azerbaijan.
Iran's President Rouhani said Wednesday that his administration welcomes the participation of Russian investors and private sectors in joining Iran infra-structural projects, semi-official Mehr news agency reported.
Iran's industry and energy, rail networks Cheap Jerseys From China , and the "North-South Corridor," extending from Russia through Azerbaijan to Iran, are the areas for cooperating between Tehran and Moscow, Rouhani said.
"So far Cheap Jerseys China , good agreements have reached between Iran and Russia in the areas of energy, peaceful nuclear technology, and transportation, but more efforts are needed to put these agreements into practice in the course of growing ties Cheap Jerseys Wholesale ," he said.
"Cooperation of Iran and Russia has been of great influence in the war against terrorism in the region," Rouhani said, adding that this cooperation and exchange of views is still of importance at the closing stages of war on terror in Syria.
"The Islamic Republic of Iran holds that any instability in the region is harmful for all countries of the region," he added.
Therefore Cheap Jerseys , Iran and Russia cooperation "has proved to the world that political settlement and security should be reinforced in Syria," he stressed.
Putin said that bilateral cooperation of Iran and Russia in energy, peaceful nuclear technology, railroad and transportation is developing and voiced Russia companies' readiness for joining project in Iran.
"Russia bears no limit in developing comprehensive ties with Iran and welcomes the growing trend of cooperation Winnipeg Jets Youth Jersey ," he stressed.
"The tripartite meeting of presidents of Iran, Russia, and Azerbaijan can play a key role in developing transportation and transit, particularly in the North-South Transit Corridor Washington Capitals Youth Jersey ," said Putin.
"Trade transactions between the two countries witnessed a jumping growth in 2016, and this trend should be maintained and accelerated," he said.
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